Pyridinium chloride → HCID 57437985, compound

HRID 1788003Notes

Reaction equation

HRID 1788003 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[N:18]1[C:26](=[O:27])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]1=[O:28])C1C=CC=CC=1.Cl.N1C=CC=CC=1>Cl>[OH:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[N:18]1[C:26](=[O:27])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]1=[O:28]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 57437984HCID 57437984, compound

Product 1

HCID 57437985HCID 57437985, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 46.14 g (0.125 mol) of 2-[5-(benzyloxy)-1H-indazol-3-yl]-1H-isoindole-1,3(2H)-dione and 143.35 g (1.24 mol) of piridine hydrochloride was heated at 180° C. for 1.5 hours. The resulting brown solution was cooled to 120° C. and slowly poured in a well stirred mixture of 800 ml of 0.5 N HCl. The precipitate was filtered off and dried: 32.26 g of product as yellow solid were obtained. Yield=92.4%.

Workup

  1. temperatureThe resulting brown solution was cooled to 120° C.
  2. additionslowly poured in a well
  3. filtrationThe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-cb931bc431374d1a867a8f9c572ac897
Source dataset
uspto-grants-2009_03
Patent number
US07511136B2

Reaction notes

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