Methane → HCID 178518411, compound

HRID 1788030Notes

Reaction equation

HRID 1788030 reaction equation
C1(N[C:8]2[C:9]3[S:28][CH2:27][CH2:26][C:10]=3N=C(N3CCN(C4C=CC=CC=4)CC3)N=2)CCCCC1.[NH2:29][C:30]([NH2:32])=[O:31].C.[OH-:34].[Na+]>>[N:29]1[C:10]2[CH:26]=[CH:27][S:28][C:9]=2[C:8]([OH:34])=[N:32][C:30]=1[OH:31]

Participants

5

Reactant 4

HCID 297MethaneHCID 1176UreaHCID 14798Sodium HydroxideHCID 11956655HCID 11956655, compound

Product 1

HCID 178518411HCID 178518411, compoundYield 75%

Procedure

10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.

Workup

  1. temperatureAfter cooling
  2. filtrationIt is filtered
  3. temperaturethe filtrate is cooled
  4. customThe precipitate formed
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-4544ba298ba94d35920fe35a794a47a2
Source dataset
uspto-grants-2009_03
Patent number
US07511045B2

Reaction notes

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