反应详情

温度

95 °C

To a solution of 6-chloro-2-(2-fluoroethyl)-5-methoxy-2-(3-oxobutyl)indan-1-one (32 g, 102 mmol) in toluene (1000 mL) were added acetic acid (7.0 mL, 120 mmol) and pyrrolidine (10 mL, 120 mmol) and the solution was heated at 95° C. for 2 hours. After cooling to room temperature, the reaction mixture was diluted with EtOAc (1000 mL), washed with water and saturated aqueous NaHCO3, and dried over MgSO4. Filtration through a pad of silica gel and removal of the solvent under vacuum gave 6-chloro-9a-(2-fluoroethyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one as a solid.

1. temperatureAfter cooling to room temperature
2. washwashed with water and saturated aqueous NaHCO3
3. dry with materialdried over MgSO4
4. filtrationFiltration
5. customthrough a pad of silica gel and removal of the solvent under vacuum