反应详情

3-Hydroxyacetophenone (136.15 g, 1 mol), potassium carbonate (414.63 g, 2 mol), KI (33.2 g, 0.2 mol), and benzyl bromide (171.04 g, 1 mol) were dissolved in acetone and the reaction mixture was refluxed while stirring for 24 hours, followed by washing with brine. The reaction mixture was extracted with ethyl acetate, the extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3) to obtain 1-(3-benzyloxyphenyl)ethanone (221.8 g, yield 98%) in an oil state.

1. temperaturethe reaction mixture was refluxed
2. washby washing with brine
3. extractionThe reaction mixture was extracted with ethyl acetate
4. dry with materialthe extract was dried over anhydrous magnesium sulfate
5. concentrationconcentrated
6. customthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3)