HRID1788458
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
A solution of 100 mg (0.23 mmol) of Compound 402a, 86 mg (0.69 mmol) of L-alaninamide, 322 mg (0.69 mmol) of PyBroP, 84 mg (0.69 mmol) DMAP and 89 mg (0.69 mmol) DIEA in 5 mL anhydrous CH2Cl2 was stirred at room temperature for 24 h. To this solution was added 214 mg (0.92 mmol) of CSA. The solution was stirred for another 24 h, diluted with 10 mL CH2Cl2 and washed with 10 mL H2O. The solvent was dried and evaporated. The residue was chromatographed on silica gel using first hexane/EtOAc then CH2Cl2/MeOH as eluent yielding 50 mg yellow oil. MS: 514.28 (M+H+).
WORKUP
后处理
- washwashed with 10 mL H2O
- customThe solvent was dried
- customevaporated
- customThe residue was chromatographed on silica gel using first hexane/EtOAc