反应详情

4-Oxo-2-phenyl-1,4-dihydro-quinoline-6-carboxylic acid (2.78 g, 1.05 mmol) was dissolved in DMF (50 mL), and HATU (1.1 eq.) and diisopropyl ethylamine (2.2 eq, 402 μL) were added. After stirring at room temperature for 15 minutes, 3-amino-4-cyclohexylamino-benzoic acid ethyl ester (2.89 g, 1.1 eq.) dissolved in 20 mL DMF was added. After stirring overnight, the reaction was evaporated, dissolved in ethyl acetate and washed with water and brine, dried with sodium sulfate, evaporated and dried overnight. The product was then refluxed in acetic acid for 4 hr, evaporated to dryness, and coevaporated 2 more times with toluene. The product was recrystallized from methanol to give 4.13 g of product.

1. additionwas added
2. stirringAfter stirring overnight
3. customthe reaction was evaporated
4. dissolutiondissolved in ethyl acetate
5. washwashed with water and brine
6. dry with materialdried with sodium sulfate
7. customevaporated
8. customdried overnight
9. temperatureThe product was then refluxed in acetic acid for 4 hr
10. customevaporated to dryness
11. customThe product was recrystallized from methanol