HRID1788651

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID312

Chloride

Cl-

HCID1117

Sulfate

O4S-2

结构：CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O

HCID249332

Vincristine sulfate

C46H58N4O14S

PRODUCTS

生成物

结构：CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.[Cl-]

HCID86741688

未命名化合物

PROCEDURE

实验过程

The sulphate of vincristine sulphate parent substance was replaced by chloride ions. Vincristine chloride produced in this way was used for the further equilibrium studies.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-23a529a4d1a3492180019eb2f35a3256
来源数据集: uspto-grants-1987_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04684638
来源说明: uspto-grants-1987_08

反应 SMILES

S([O-])([O-])(=O)=O.[CH3:6][CH2:7][C@@:8]1([OH:65])[CH2:19][N:17]2[CH2:18][C@@H:10]([CH2:11][C@:12]([C:61]([O:63][CH3:64])=[O:62])([C:27]3[CH:32]=[C:31]4[C@@:33]56[C@@H:44]([N:45]([CH:46]=[O:47])[C:30]4=[CH:29][C:28]=3[O:59][CH3:60])[C@@:43]([OH:52])([C:48]([O:50][CH3:51])=[O:49])[C@H:42]([O:53][C:54]([CH3:56])=[O:55])[C@:38]3([CH2:57][CH3:58])[CH:39]=[CH:40][CH2:41][N:36]([C@H:37]53)[CH2:35][CH2:34]6)[C:13]3[NH:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:14]=3[CH2:15][CH2:16]2)[CH2:9]1.OS(O)(=O)=O.[Cl-:71]>>[CH3:6][CH2:7][C@@:8]1([OH:65])[CH2:19][N:17]2[CH2:18][C@@H:10]([CH2:11][C@:12]([C:61]([O:63][CH3:64])=[O:62])([C:27]3[CH:32]=[C:31]4[C@:33]56[C@@H:37]7[C@:38]([CH2:57][CH3:58])([C@@H:42]([O:53][C:54]([CH3:56])=[O:55])[C@:43]([OH:52])([C:48]([O:50][CH3:51])=[O:49])[C@@H:44]5[N:45]([CH:46]=[O:47])[C:30]4=[CH:29][C:28]=3[O:59][CH3:60])[CH:39]=[CH:40][CH2:41][N:36]7[CH2:35][CH2:34]6)[C:13]3[NH:26][C:25]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:14]=3[CH2:15][CH2:16]2)[CH2:9]1.[Cl-:71]