Chloride → Vincristine chloride

HRID 1788651Notes

Reaction equation

S([O-])([O-])(=O)=O.[CH3:6][CH2:7][C@@:8]1([OH:65])[CH2:19][N:17]2[CH2:18][C@@H:10]([CH2:11][C@:12]([C:61]([O:63][CH3:64])=[O:62])([C:27]3[CH:32]=[C:31]4[C@@:33]56[C@@H:44]([N:45]([CH:46]=[O:47])[C:30]4=[CH:29][C:28]=3[O:59][CH3:60])[C@@:43]([OH:52])([C:48]([O:50][CH3:51])=[O:49])[C@H:42]([O:53][C:54]([CH3:56])=[O:55])[C@:38]3([CH2:57][CH3:58])[CH:39]=[CH:40][CH2:41][N:36]([C@H:37]53)[CH2:35][CH2:34]6)[C:13]3[NH:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:14]=3[CH2:15][CH2:16]2)[CH2:9]1.OS(O)(=O)=O.[Cl-:71]>>[CH3:6][CH2:7][C@@:8]1([OH:65])[CH2:19][N:17]2[CH2:18][C@@H:10]([CH2:11][C@:12]([C:61]([O:63][CH3:64])=[O:62])([C:27]3[CH:32]=[C:31]4[C@:33]56[C@@H:37]7[C@:38]([CH2:57][CH3:58])([C@@H:42]([O:53][C:54]([CH3:56])=[O:55])[C@:43]([OH:52])([C:48]([O:50][CH3:51])=[O:49])[C@@H:44]5[N:45]([CH:46]=[O:47])[C:30]4=[CH:29][C:28]=3[O:59][CH3:60])[CH:39]=[CH:40][CH2:41][N:36]7[CH2:35][CH2:34]6)[C:13]3[NH:26][C:25]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:14]=3[CH2:15][CH2:16]2)[CH2:9]1.[Cl-:71]

Participants

Reactant 3

HCID 312Chloride

HCID 1117Sulfate Ion

HCID 249332Vincristine Sulfate

Product 1

HCID 86741688Vincristine chloride

Procedure

The sulphate of vincristine sulphate parent substance was replaced by chloride ions. Vincristine chloride produced in this way was used for the further equilibrium studies.

Sources & evidence

ORD record: ord-23a529a4d1a3492180019eb2f35a3256
Source dataset: uspto-grants-1987_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04684638

Reaction notes

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