2-Methylpiperidine → HCID 13336378, compound

HRID 1788730Notes

Reaction equation

HRID 1788730 reaction equation
[C:1]1([C:7]2[N:16]=[C:15]([C:17]([O:19]CC)=O)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][NH:24]1.C([Li])CCC>CCCCCC.O1CCCC1>[CH3:22][CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][N:24]1[C:17]([C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:16]=1)=[O:19]

Participants

6

Reactant 3

HCID 79742-MethylpiperidineHCID 20158356HCID 20158356, compoundHCID 178418339Butyllithium

Product 1

HCID 13336378HCID 13336378, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8058HexaneSolvent

Procedure

The procedure of Example 24 is followed using ethyl 2-phenylquinazoline-4-carboxylate (3 g), 2-methylpiperidine (3 ml), a 1.6M solution of butyllithium in hexane (15 ml) and tetrahydrofuran (20 ml) as the starting materials. After recrystallisation from ethanol, 2-methyl-1-[(2-phenylquinazolin-4yl)-carbonyl]-piperidine (1.7 g), melting at 150° C., is obtained.

Workup

  1. customAfter recrystallisation from ethanol, 2-methyl-1-[(2-phenylquinazolin-4yl)-carbonyl]-piperidine (1.7 g), melting at 150° C.
  2. customis obtained

Sources & evidence

ORD record
ord-c1dcd63c5c9042e1aa630b0cfe35ca4a
Source dataset
uspto-grants-1987_08
Patent number
US04684652

Reaction notes

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