Hydrochloric Acid → HCID 4568593, compound

HRID 1788733Notes

Reaction equation

HRID 1788733 reaction equation
Cl.Cl.[CH2:3]([N:7]([CH2:27][CH:28]([CH3:30])[CH3:29])[C:8]([C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[C:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[CH:11]=1)=[O:9])[CH:4]([CH3:6])[CH3:5]>C(OCC)(=O)C.CC(C)=O.CCOCC>[CH2:3]([N:7]([CH2:27][CH:28]([CH3:30])[CH3:29])[C:8]([C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[C:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[CH:11]=1)=[O:9])[CH:4]([CH3:6])[CH3:5]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 13336353HCID 13336353, compound

Product 1

HCID 4568593HCID 4568593, compound

Reagents, catalysts & solvents 3

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

The residue obtained is dissolved in ethyl acetate (100 ml) and the organic phase is extracted with a normal solution of acetic acid (100 ml), washed with water (4×100 ml), dried over magnesium sulphate and evaporated under reduced pressure. The residue obtained is taken up in acetone and, after the addition of a solution of hydrogen chloride in ether, N,N-diisobutyl-2-(2-chlorophenyl)-quinoline-4-carboxamide hydrochloride (1.5 g), melting at 124° C., is isolated.

Workup

  1. customThe residue obtained
  2. extractionthe organic phase is extracted with a normal solution of acetic acid (100 ml)
  3. washwashed with water (4×100 ml)
  4. dry with materialdried over magnesium sulphate
  5. customevaporated under reduced pressure
  6. customThe residue obtained
  7. customis isolated

Sources & evidence

ORD record
ord-690bbacae3954003b2a46a08e421f65b
Source dataset
uspto-grants-1987_08
Patent number
US04684652

Reaction notes

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