Phenylhydrazine → 1-Phenylpyrazol-5-ylamine

HRID 1788858Notes

Reaction equation

HRID 1788858 reaction equation
[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:10](=[CH2:13])[C:11]#[N:12].[OH-].[Na+]>O>[C:1]1([N:7]2[C:11]([NH2:12])=[CH:10][CH:13]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 7516PhenylhydrazineHCID 14798Sodium HydroxideHCID 701982-Chloroacrylonitrile

Product 1

HCID 700061-Phenylpyrazol-5-ylamine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture consisting of 680 parts water, 216 parts of phenylhydrazine and 164 parts of 2-chloroacrylonitrile 220 parts of a 30% sodium hydroxide solution are added dropwise at room temperature. After six hours the reaction is completed. The resulting 1-phenyl-5-aminopyrazole is isolated from that phase which has been separated by the addition of sodium chloride.

Workup

  1. additionare added dropwise at room temperature

Sources & evidence

ORD record
ord-4fc6a07ca93446d38317ff7a8bd2f484
Source dataset
uspto-grants-1987_08
Patent number
US04685934

Reaction notes

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