Ethyl Acrylate → 4-Ethoxycarbonylethyl-1-formylpiperazine

HRID 1788970Notes

Reaction equation

HRID 1788970 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[CH:8]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:9]>C(Cl)(Cl)Cl>[CH2:6]([O:5][C:1]([CH2:2][CH2:3][N:13]1[CH2:14][CH2:15][N:10]([CH:8]=[O:9])[CH2:11][CH2:12]1)=[O:4])[CH3:7]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 821911-Piperazinecarboxaldehyde

Product 1

HCID 143997854-Ethoxycarbonylethyl-1-formylpiperazineYield 96.6%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Ethyl acrylate (326 g) and chloroform (2 liters) are added to 1-formylpiperazine (320 g) and the mixture is stirred at room temperature for 3 days. The solvent is evaporated under reduced pressure to yield crude 4-ethoxycarbonylethyl-1-formylpiperazine (580 g) as an orange oil.

Workup

  1. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-01666c198ac543a5af6a980a234f5f81
Source dataset
uspto-grants-1987_08
Patent number
US04686221

Reaction notes

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