反应详情

温度

50 °C

Over a 15 minute period, 149 g. (2.7 moles) of ground potassium hydroxide is added to 180 g. (0.96 mole) of 1-hydroxy-2-naphthoic acid in 2.5 l. of dimethylformamide (during the course of which the temperature rises to 32° C.). The reaction mixture is stirred at 20°-25° C. for 16 hours and at 50° C. for 2 hours and cooled to 40° C. 387 g. (2.7 moles) of methyl iodide is added, and the reaction mixture is stirred at 40°-50° C. for 4 hours. 4 l. of saturated sodium chloride solution is added, and the mixture is extracted with diethyl ether. The diethyl ether extract is dried over anhydrous sodium sulfate and evaporated at reduced pressure to obtain the crude product as a light brown oil (255 g.).

1. customrises to 32° C.
2. temperaturecooled to 40° C
3. stirringthe reaction mixture is stirred at 40°-50° C. for 4 hours
4. extractionthe mixture is extracted with diethyl ether
5. extractionThe diethyl ether extract
6. dry with materialis dried over anhydrous sodium sulfate
7. customevaporated at reduced pressure