反应详情

A solution of 2,3-dichlorobenzaldehyde (1.57 g, 8.9 mmoles), cyclobutyl 3-oxobutanoate (1.4 g, 8.9 mmoles), piperidine (8 drops) and hexanoic acid (11 drops) in dry benzene (100 ml) was heated at reflux for 12 hours using a Dean and Stark apparatus. The solution was allowed to cool to room temperature and the solvent removed in vacuo to leave the crude sub-title compound as an oil 3.5 g. Chromatography on silica eluting with petroleum ether (60°-80° )/ethyl acetate mixtures afforded the sub-title compound as an oil, 1.7 g.

1. temperatureat reflux for 12 hours
2. customthe solvent removed in vacuo
3. customto leave the crude sub-title compound as an oil 3.5 g