反应详情

温度

80 °C

Sodium hydride (3.1 g, 77.1 mmol) and diethyl carbonate were combined with 3-methylacetophenone (4.5 g, 33.54 mmol). The mixture was stirred for 2 hours at 80° C. After the reaction was completed, ice water and acetic acid were added thereto. Then, the mixture was extracted with ethyl acetate/saturated sodium chloride. The extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography to obtain 3-oxo-3-m-tolylpropionate ethyl ester (5.8 g, yield 84%).

1. extractionThen, the mixture was extracted with ethyl acetate/saturated sodium chloride
2. dry with materialThe extract was dried over anhydrous magnesium sulfate
3. concentrationconcentrated
4. customthe resulting residue was purified by column chromatography