1-Methylpiperazine → HCID 13937762, compound

HRID 1789184Notes

Reaction equation

HRID 1789184 reaction equation
[CH3:1][CH:2]1[N:7]2[C:8]3[O:20][NH:19][C:18](=[O:21])[C:9]=3[C:10](=[O:17])[C:11]3=[CH:12][C:13]([F:16])=[C:14](F)[C:5](=[C:6]23)[O:4][CH2:3]1.[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>N1C=CC=CC=1>[CH3:1][CH:2]1[N:7]2[C:8]3[O:20][NH:19][C:18](=[O:21])[C:9]=3[C:10](=[O:17])[C:11]3=[CH:12][C:13]([F:16])=[C:14]([N:26]4[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]4)[C:5](=[C:6]23)[O:4][CH2:3]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 13937761HCID 13937761, compound

Product 1

HCID 13937762HCID 13937762, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 1.45 g of the preceding isoxazolo-pyrido-benzoxazine derivative (9) (R8 =CH3) in 30 ml pyridine is added in 2.5 ml N-methylpiperazine. It is then heated under nitrogen atmosphere at 50° C. for 24 hours. The mixture is evaporated to dryness and is then boiled in ethanol for 5 minutes and the mixture is filtered and washed with water yielding the 1-methyl-4-(4-methyl-1-piperazinyl)-5-fluoro-1,2,8,9-tetrahydro-7H-isoxazolo[4',5':5,6]pyrido[1,2,3-de][1,4]benzoxazine-7,8-dione (I) ##STR15## R=CH3).

Workup

  1. customThe mixture is evaporated to dryness
  2. filtrationthe mixture is filtered
  3. washwashed with water yielding the 1-methyl-4-(4-methyl-1-piperazinyl)-5-fluoro-1,2,8,9-tetrahydro-7H-isoxazolo[4',5':5,6]pyrido[1,2,3-de][1,4]benzoxazine-7,8-dione (I) ##STR15## R=CH3)

Sources & evidence

ORD record
ord-34ce3bda32144174ae81e48126bff7e2
Source dataset
uspto-grants-1987_08
Patent number
US04687770

Reaction notes

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