反应详情

A mixture of 3.88 g of 2-hydroxybenzaldehyde sodium salt, 7.00 g of 1-(3-chloropropyl)-4-phenylpiperazine dihydrochloride, 6.80 g of potassium carbonate and 50 ml of dimethylformamide is stirred at 60° to 70° C. for 15 hours under nitrogen atmosphere, and is concentrated under reduced pressure to remove solvent. Water is added to the residue, and the aqueous mixture is extracted with ether. The extract is washed with water, dried and concentrated under reduced pressure to remove solvent. The residue is purified by silica gel chromatography (solvent, chloroform:methanol=99:1). 5.42 g of 2-[3-(4-phenylpiperazin-1-yl)propyloxy]benzaldehyde are obtained as an oil.

1. concentrationis concentrated under reduced pressure
2. customto remove solvent
3. additionWater is added to the residue
4. extractionthe aqueous mixture is extracted with ether
5. washThe extract is washed with water
6. customdried
7. concentrationconcentrated under reduced pressure
8. customto remove solvent
9. customThe residue is purified by silica gel chromatography (solvent, chloroform:methanol=99:1)