反应详情

温度

50 °C

A mixture of 1.56 g of 2-(hydroxymethyl)thiophenol, 3.77 g of 1-(3-chloropropyl)-4-phenylpiperazine dihydrochloride, 5.02 g of potassium carbonate and 40 ml of dimethylformamide is stirred at 50° C. for 6 hours. Insoluble materials are filtered off, and the filtrate is concentrated under reduced pressure to remove solvent. Water is added to the residue, and the aqueous mixture is extracted with ethyl acetate. The extract is washed with water, dried and concentrated under reduced pressure to remove solvent. The residue is digested with n-hexane and collected by filtration. 3.42 g of 2-[3-(4-phenylpiperazin-1-yl)propylthio]benzylalcohol are obtained. Yield: 91%.

1. filtrationInsoluble materials are filtered off
2. concentrationthe filtrate is concentrated under reduced pressure
3. customto remove solvent
4. additionWater is added to the residue
5. extractionthe aqueous mixture is extracted with ethyl acetate
6. washThe extract is washed with water
7. customdried
8. concentrationconcentrated under reduced pressure
9. customto remove solvent
10. filtrationcollected by filtration