Imidazole → HCID 20188399, compound

HRID 1789529Notes

Reaction equation

HRID 1789529 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6].[Si:7](Cl)([C:10](C)(C)C)([CH3:9])[CH3:8].N1[CH:19]=[CH:18]N=C1.[CH3:20]N(C)C=O>>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][Si:7]([CH2:10][CH:18]([CH3:19])[CH3:20])([CH3:9])[CH3:8]

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 135694-Chloro-1-butanolHCID 28928tert-Butyldimethylsilyl chloride

Product 1

HCID 20188399HCID 20188399, compound

Procedure

The procedure followed is the same as that described in Example 19 substituting 4-chlorobutanol (326 g, 3.00 moles), tert-butyldimethylsilyl chloride (500 g, 3.31 moles), imidazole (225 g, 3.30 mmoles), and dimethylformamide (1600 ml). The crude product is fractionally distilled under reduced vacuum leaving a clear, colorless oil (476 g, 2.13 moles), BP 60° C./0.3 mm.

Workup

  1. distillationThe crude product is fractionally distilled under reduced vacuum

Sources & evidence

ORD record
ord-ff888ae3a7c44055b46ba6e76b9b5081
Source dataset
uspto-grants-1987_08
Patent number
US04689349

Reaction notes

Loading…