Hydrochloric Acid → Ethyl (2S)-2-amino-4-phenylbutanoate--hydrogen chloride (1/1)

HRID 1789667Notes

Reaction equation

HRID 1789667 reaction equation
[ClH:1].[NH2:2][C@H:3]([C:12]([OH:14])=[O:13])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH2:15](O)[CH3:16]>>[ClH:1].[CH2:15]([O:13][C:12](=[O:14])[C@H:3]([CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH2:2])[CH3:16]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 2724505(S)-2-amino-4-phenylbutanoic acid

Product 1

HCID 2734606Ethyl (2S)-2-amino-4-phenylbutanoate--hydrogen chloride (1/1)

Procedure

Hydrogen chloride gas is bubbled through a solution of (L)-homophenylalanine (5.13 g, 28.7 mmol) in 100 mL of ethanol for 5 minutes. The mixture is stirred at room temperature for 16 hours. The mixture is concentrated in vacuo to yield L-homophenylalanine ethyl ester hydrochloride as a white solid.

Workup

  1. concentrationThe mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-9c82313f2b26441a97fe05b17f01ced8
Source dataset
uspto-grants-2006_07
Patent number
US07071169B2

Reaction notes

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