1-Ethylpiperazine → HCID 22036344, compound

HRID 1789689Notes

Reaction equation

HRID 1789689 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH:10]2[O:15][C:14]3[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=3[O:12][CH2:11]2)=[N:6][CH:5]=[CH:4][N:3]=1.[CH2:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[CH3:21]>>[CH2:20]([N:22]1[CH2:27][CH2:26][N:25]([C:2]2[C:7]([O:8][CH2:9][CH:10]3[O:15][C:14]4[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=4[O:12][CH2:11]3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:24][CH2:23]1)[CH3:21]

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 22036545HCID 22036545, compound

Product 1

HCID 22036344HCID 22036344, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-(2,3-dihydro-1,4-benzodioxin-2-ylmethoxy)pyrazine* (150 mg, 0.54 mmol) and N-ethylpiperazine (219 mg, 1.92 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 128 mg (66%) of the title product. HRMS m/z calcd for C19H24N4O3(M)+356.1848, found 356.1848. Anal. (C19H24N4O3) C, H, N.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-42499fdd3c6846ccb99c1096b54c7f10
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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