Phosphorus oxychloride → HCID 22036901, compound

HRID 1789783Notes

Reaction equation

HRID 1789783 reaction equation
O[C:2]1[C:3]2[S:10][C:9]([C:11]3[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=3)=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.C(N(C(C)C)CC)(C)C.P(Cl)(Cl)([Cl:30])=O>>[Cl:30][C:2]1[C:3]2[S:10][C:9]([C:11]3[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=3)=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 178424825HCID 178424825, compound

Product 1

HCID 22036901HCID 22036901, compound

Conditions

Temperature
100 °C

Procedure

The hydroxy compound prepared in Step 1 was treated with phosphorous oxychloride (150 mL) and diisopropylethylamine (2 mL). The mixture was then heated at 100° C. for 4 hours. The solvents were evaporated under reduced pressure and the residue was carefully treated with ice water. The resulting solid was filtered off and crystallized from ethanol.

Workup

  1. customThe solvents were evaporated under reduced pressure
  2. additionthe residue was carefully treated with ice water
  3. filtrationThe resulting solid was filtered off
  4. customcrystallized from ethanol

Sources & evidence

ORD record
ord-b005b6f337a44f94b9a0bf0c978e4792
Source dataset
uspto-grants-2006_07
Patent number
US07071190B2

Reaction notes

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