2-Acetylsulfanylmethyl-3-(2-amino-pyridin-4-yl)-propionic acid ethyl ester → 2-(2-Amino-pyridin4-ylmethyl)-3-mercapto-propionic acid

HRID 1789801Notes

Reaction equation

HRID 1789801 reaction equation
C([O:3][C:4](=[O:19])[CH:5]([CH2:14][S:15]C(=O)C)[CH2:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[CH:8]=1)C>Cl>[NH2:13][C:9]1[CH:8]=[C:7]([CH2:6][CH:5]([CH2:14][SH:15])[C:4]([OH:19])=[O:3])[CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 1

HCID 541499282-Acetylsulfanylmethyl-3-(2-amino-pyridin-4-yl)-propionic acid ethyl ester

Product 1

HCID 101767122-(2-Amino-pyridin4-ylmethyl)-3-mercapto-propionic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Acetylsulfanylmethyl-3-(2-amino-pyridin4-yl)-propionic acid ethyl ester (52 mg, 0.13 mmol) was dissolved in conc. HCl (2 mL) under argon. The solution was heated to reflux for 1 h. Concentration under reduced pressure gave the title compound as the hydrochloride salt (32 mg, 100%).

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 1 h
  3. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-4bf3e9ebafb04352b1ad44652b3c3909
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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