HCID 54210448, compound → HCID 9837241, compound

HRID 1789810Notes

Reaction equation

HRID 1789810 reaction equation
C([O:3][C:4](=[O:26])[CH:5]([CH2:21][S:22]C(=O)C)[CH2:6][C:7]1[CH:8]=[N:9][C:10]([NH:13]C(OC(C)(C)C)=O)=[CH:11][CH:12]=1)C>Cl>[NH2:13][C:10]1[N:9]=[CH:8][C:7]([CH2:6][CH:5]([CH2:21][SH:22])[C:4]([OH:26])=[O:3])=[CH:12][CH:11]=1

Participants

3

Reactant 1

HCID 54210448HCID 54210448, compound

Product 1

HCID 9837241HCID 9837241, compoundYield 126.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-propionic acid ethyl ester (38 mg, 0.096 mmol) was dissolved in conc. HCl (2.0 mL) under argon. The solution was stirred at room temperature for 1 h and then heated to reflux for 1 h. Concentration under reduced pressure gave the title compound (25.7 mg, 100%) as the hydrochloride salt.

Workup

  1. temperatureheated
  2. temperatureto reflux for 1 h
  3. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-c422c5c80ac74dc8a85345718451f205
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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