HCID 53958532, compound → HCID 10130758, compound

HRID 1789814Notes

Reaction equation

HRID 1789814 reaction equation
C([O:5][C:6](=[O:29])[C:7]([CH2:24][S:25]C(=O)C)([CH3:23])[CH2:8][C:9]1[CH:10]=[N:11][C:12]([NH:15]C(OC(C)(C)C)=O)=[CH:13][CH:14]=1)(C)(C)C>Cl>[NH2:15][C:12]1[N:11]=[CH:10][C:9]([CH2:8][C:7]([CH2:24][SH:25])([CH3:23])[C:6]([OH:29])=[O:5])=[CH:14][CH:13]=1

Participants

3

Reactant 1

HCID 53958532HCID 53958532, compound

Product 1

HCID 10130758HCID 10130758, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-methyl-propionic acid tert-butyl ester (4 mg, 9.4 μmol) was dissolved in conc. HCl under argon. The solution was heated to reflux for 1 h. Concentration under reduced pressure yielded the title compound as the hydrochloride salt (2.5 mg, 100%).

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 1 h
  3. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-e888b47742fc4305b15e5deb0b2c9806
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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