HCID 54067761, compound → HCID 9794764, compound

HRID 1789818Notes

Reaction equation

HRID 1789818 reaction equation
C([O:3][C:4](=[O:28])[C:5]([CH2:23][S:24]C(=O)C)([CH2:8][C:9]1[CH:10]=[N:11][C:12]([NH:15]C(OC(C)(C)C)=O)=[CH:13][CH:14]=1)[CH2:6][CH3:7])C>Cl>[NH2:15][C:12]1[N:11]=[CH:10][C:9]([CH2:8][C:5]([CH2:23][SH:24])([CH2:6][CH3:7])[C:4]([OH:28])=[O:3])=[CH:14][CH:13]=1

Participants

3

Reactant 1

HCID 54067761HCID 54067761, compound

Product 1

HCID 9794764HCID 9794764, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Acetylsulfanylmethyl-2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-butyric acid ethyl ester (12.3 mg, 30 μmol) was dissolved in conc. HCl (2 mL) under argon. The solution was heated to reflux for 24 h. Concentration under reduced pressure gave the title compound as the hydrochloride salt (8.3 mg, 100%).

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 24 h
  3. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-cfa2598c674d45cd8384f953ab1e1107
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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