Trifluoroacetic acid → HCID 86760119, compound

HRID 1789871Notes

Reaction equation

HRID 1789871 reaction equation
C(O)(C(F)(F)F)=O.[CH2:8]([O:10][C:11](=[O:40])[CH:12]([CH2:35][S:36][C:37](=[O:39])[CH3:38])[CH2:13][C:14]1[CH:15]=[N:16][C:17]([N:20](C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=[N:18][CH:19]=1)[CH3:9]>C(Cl)Cl>[CH2:8]([O:10][C:11](=[O:40])[CH:12]([CH2:35][S:36][C:37](=[O:39])[CH3:38])[CH2:13][C:14]1[CH:15]=[N:16][C:17]([NH2:20])=[N:18][CH:19]=1)[CH3:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54460231HCID 54460231, compound

Product 1

HCID 86760119HCID 86760119, compoundYield 132%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1.5 mL) was added to a solution of 2-acetylsulfanylmethyl-3-(2-[N,N-bis(tert-butoxycarbonyl)amino]-pyrimidin-5-yl)-propionic acid ethyl ester (225 mg, 0.46 mmol) in methylene chloride (1.5 mL). The reaction was stirred for 120 min and concentrated under reduced pressure to give the title compound (172 mg, 94%) as the TFA salt.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2ddc12cb8a4744238f5c2c85ca990667
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

Loading…