HCID 54201262, compound → HCID 22036122, compound

HRID 1789877Notes

Reaction equation

HRID 1789877 reaction equation
C([O:3][C:4](=[O:28])[CH:5]([CH2:13][C:14]1[CH:15]=[N:16][C:17]([NH:20]C(OC(C)(C)C)=O)=[CH:18][CH:19]=1)[CH:6]([S:9]C(=O)C)[CH2:7][CH3:8])C>Cl>[NH2:20][C:17]1[N:16]=[CH:15][C:14]([CH2:13][CH:5]([CH:6]([SH:9])[CH2:7][CH3:8])[C:4]([OH:28])=[O:3])=[CH:19][CH:18]=1

Participants

3

Reactant 1

HCID 54201262HCID 54201262, compound

Product 1

HCID 22036122HCID 22036122, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3-acetylsulfanyl-2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-pentanoic acid ethyl ester/B (51.6 mg; 0.13 mmol) in concentrated HCl (2 mL) was refluxed under argon for 1.5 hours. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure to afford 34.7 mg of the title compound as the hydrochloride salt.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7acc4118a688498fb1276bc4af28fcef
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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