HCID 54294565, compound → HCID 22036157, compound

HRID 1789884Notes

Reaction equation

HRID 1789884 reaction equation
C([O:3][C:4](=[O:27])[CH:5]([CH2:22][S:23]C(=O)C)[CH2:6][C:7]1[CH:8]=[N:9][C:10]([NH:14]C(OC(C)(C)C)=O)=[C:11]([Cl:13])[CH:12]=1)C>Cl>[NH2:14][C:10]1[N:9]=[CH:8][C:7]([CH2:6][CH:5]([CH2:22][SH:23])[C:4]([OH:27])=[O:3])=[CH:12][C:11]=1[Cl:13]

Participants

3

Reactant 1

HCID 54294565HCID 54294565, compound

Product 1

HCID 22036157HCID 22036157, compoundYield 110.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 2-acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-5-chloro-pyridin-3-yl)-propionic acid ethyl ester (55mg, 0.132 mmol) in concentrated HCl (4 mL) was refluxed for 90 min. The reaction was cooled and concentrated under reduced pressure to give the title compound as the HCl salt (36mg, 96.4%)

Workup

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2a9d04f03e0041fab320d6b1e0866204
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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