Hydrochloric Acid → HCID 22036012, compound

HRID 1789908Notes

Reaction equation

HRID 1789908 reaction equation
Cl.C([O:4][C:5](=[O:29])[CH:6]([CH2:24][S:25]C(=O)C)[CH:7]([C:10]1[CH:11]=[N:12][C:13]([NH:16]C(OC(C)(C)C)=O)=[CH:14][CH:15]=1)[CH2:8][CH3:9])C>>[NH2:16][C:13]1[N:12]=[CH:11][C:10]([CH:7]([CH2:8][CH3:9])[CH:6]([CH2:24][SH:25])[C:5]([OH:29])=[O:4])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54435146HCID 54435146, compound

Product 1

HCID 22036012HCID 22036012, compound

Procedure

Hydrochloric acid (38%, 4 mL) was added to 2-acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-pentanoic acid ethyl ester (0.041 g, 0.1 mmol) under argon and the mixture was heated to reflux for 4 h. Concentration under reduced pressure and drying (45° C., 0.3 mbar) afforded the title compound as the hydrochloride salt (0.027 mg, 97%).

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 h
  3. concentrationConcentration under reduced pressure
  4. customdrying (45° C., 0.3 mbar)

Sources & evidence

ORD record
ord-8eec2afd44f04db6900dd76d091ef212
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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