HCID 53756755, compound → HCID 22036108, compound

HRID 1789919Notes

Reaction equation

HRID 1789919 reaction equation
C([O:3][C:4](=[O:33])[CH:5]([CH2:28][S:29]C(=O)C)[CH:6]([C:14]1[CH:15]=[N:16][C:17]([NH:20]C(OC(C)(C)C)=O)=[CH:18][CH:19]=1)[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)C>Cl>[NH2:20][C:17]1[N:16]=[CH:15][C:14]([CH:6]([CH2:7][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:5]([CH2:28][SH:29])[C:4]([OH:33])=[O:3])=[CH:19][CH:18]=1

Participants

3

Reactant 1

HCID 53756755HCID 53756755, compound

Product 1

HCID 22036108HCID 22036108, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)4-phenyl-butyric acid ethyl ester (0.14 g, 0.3 mmol) was dissolved in conc. HCl (5.0 mL). The solution was heated to reflux for 4.5 h under argon. Concentration under reduced pressure gave the title compound as the hydrochloride salt (100 mg, 98%).

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 4.5 h under argon
  3. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-1cfb6a7fe4ee45cf909ed85a4f33fcad
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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