反应详情

Etylacetate saturated with HCl (g) (15 mL) was added to a solution of 3-[3-(6tert-butoxycarbonylamino-pyridin-3-yl)-2-ethoxycarbonyl-propyldisulfanyl]-2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-propionic acid ethyl ester (130 mg, 0.191 mmol) in ethylacetate (7 mL) at 0° C. The reaction was allowed to attain room temperature and was stirred for 19 h, then evaporated under reduced pressure. The residue was dissolved in water, saturated aqueous Na2CO3 was added and the aqueous phase was extracted with CH2Cl2. The organic layer was dried and concentrated under reduced pressure to give the title compound (90 mg, 98%).

1. customto attain room temperature
2. customevaporated under reduced pressure
3. dissolutionThe residue was dissolved in water
4. additionsaturated aqueous Na2CO3 was added
5. extractionthe aqueous phase was extracted with CH2Cl2
6. customThe organic layer was dried
7. concentrationconcentrated under reduced pressure