HCID 53847096, compound → HCID 22036151, compound

HRID 1789928Notes

Reaction equation

HRID 1789928 reaction equation
C([O:3][C:4](=[O:28])[CH:5]([CH2:23][S:24]C(=O)C)[CH:6]([C:10]1[CH:11]=[N:12][C:13]([NH:16]C(=O)C(C)(C)C)=[CH:14][CH:15]=1)[CH2:7][CH2:8][CH3:9])C>Cl>[NH2:16][C:13]1[N:12]=[CH:11][C:10]([CH:6]([CH2:7][CH2:8][CH3:9])[CH:5]([CH2:23][SH:24])[C:4]([OH:28])=[O:3])=[CH:15][CH:14]=1

Participants

3

Reactant 1

HCID 53847096HCID 53847096, compound

Product 1

HCID 22036151HCID 22036151, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Acetylsulfanylmethyl-3-[6-(2,2-dimethyl-propionylamino)-pyridin-3-yl]-hexanoic acid ethyl ester (40.4 mg, 99 μmol) was dissolved under argon in aqueous hydrochloric acid (37%, 4.2 mL) and heated under reflux for 2 h. Concentration under reduced pressure (0.3 torr, 40° C.) gave the title compound as the hydrochloride salt (28 mg, 97%).

Workup

  1. temperatureheated
  2. temperatureunder reflux for 2 h
  3. concentrationConcentration under reduced pressure (0.3 torr, 40° C.)

Sources & evidence

ORD record
ord-2fe91ed6f0d34deca63adedf15b027ff
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

Loading…