Acetyl chloride → HCID 22041586, compound

HRID 1790250Notes

Reaction equation

HRID 1790250 reaction equation
F[C:2](F)(F)[C:3](O)=[O:4].[NH2:8][CH:9]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][N:24]2[C:28]3[CH:29]=[CH:30][C:31]([C:33](=[O:40])[C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[CH:32][C:27]=3[S:26][C:25]2=[O:41])=[CH:17][CH:16]=1)[C:10]([O:12][CH3:13])=[O:11].C(N(CC)CC)C.C(Cl)(=O)C>C(OCC)(=O)C>[C:3]([NH:8][CH:9]([CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][CH2:22][CH2:23][N:24]2[C:28]3[CH:29]=[CH:30][C:31]([C:33](=[O:40])[C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)=[CH:32][C:27]=3[S:26][C:25]2=[O:41])=[CH:19][CH:20]=1)[C:10]([O:12][CH3:13])=[O:11])(=[O:4])[CH3:2]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 22041482HCID 22041482, compound

Product 1

HCID 22041586HCID 22041586, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

500 mg of the compound obtained in Step A of Example 12 are dissolved in 10 ml of ethyl acetate; 0.353 ml of triethylamine is then added and the temperature is lowered to 0° C. 0.121 ml of acetyl chloride is added and the mixture is allowed to return to ambient temperature and is stirred overnight.

Workup

  1. customis lowered to 0° C
  2. customto return to ambient temperature

Sources & evidence

ORD record
ord-d82f864ac1fb47c593bfbc678401124d
Source dataset
uspto-grants-2006_07
Patent number
US07071221B2

Reaction notes

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