反应详情

A solution of the compound obtained in Step A of Example 31 (500 mg) and hydroxylamine hydrochloride (137 mg) in 10 ml of pyridine is heated at reflux for 3 hours. The reaction mixture is hydrolysed using 100 ml of ice-cold water and is acidified using 6N HCl. The precipitate obtained is then filtered off, washed with water and then with petroleum ether and purified on silica gel (eluant AcOEt/PE 2/8) to yield the title compound in the form of a white powder.

1. temperatureat reflux for 3 hours
2. customThe precipitate obtained
3. filtrationis then filtered off
4. washwashed with water
5. customwith petroleum ether and purified on silica gel (eluant AcOEt/PE 2/8)