反应详情

温度

50 °C

56 g of acetoacetic acid methyl ester 3 is dissolved in 500 ml of acetone, and 276.2 g of potassium carbonate as well as 86 ml of dibromoethane are added while being cooled with ice. It is heated under nitrogen to 50° C. and stirred for 72 hours at this temperature. After cooling, the mixture is diluted with ethyl acetate, washed with water and saturated sodium chloride solution, dried on sodium sulfate and concentrated by evaporation. The residue is distilled in a vacuum, whereby 66 g of the title compound is obtained as a colorless oil.

1. temperaturewhile being cooled with ice
2. temperatureAfter cooling
3. washwashed with water and saturated sodium chloride solution
4. customdried on sodium sulfate
5. concentrationconcentrated by evaporation
6. distillationThe residue is distilled in a vacuum