Hydrochloric Acid → HCID 131725845, compound

HRID 1791064Notes

Reaction equation

CC1C=CC([O:8][S:9]([C:12]2[CH:13]=[C:14]([NH:18][S:19]([C:22]3[CH:31]=[C:30]4[C:25]([CH:26]=[CH:27][C:28]([NH:32][C:33]([NH:35][C:36]5[CH:45]=[C:44]6[C:39]([CH:40]=[CH:41][C:42]([S:46]([OH:49])(=[O:48])=[O:47])=[CH:43]6)=[CH:38][CH:37]=5)=[O:34])=[CH:29]4)=[CH:24][CH:23]=3)(=[O:21])=[O:20])[CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])=CC=1.[OH-].[Na+:51].Cl>>[Na+:51].[Na+:51].[S:9]([C:12]1[CH:13]=[C:14]([NH:18][S:19]([C:22]2[CH:31]=[C:30]3[C:25]([CH:26]=[CH:27][C:28]([NH:32][C:33]([NH:35][C:36]4[CH:45]=[C:44]5[C:39]([CH:40]=[CH:41][C:42]([S:46]([O-:49])(=[O:47])=[O:48])=[CH:43]5)=[CH:38][CH:37]=4)=[O:34])=[CH:29]3)=[CH:24][CH:23]=2)(=[O:20])=[O:21])[CH:15]=[CH:16][CH:17]=1)([OH:11])(=[O:10])=[O:8].[S:9]([C:12]1[CH:13]=[C:14]([NH:18][S:19]([C:22]2[CH:31]=[C:30]3[C:25]([CH:26]=[CH:27][C:28]([NH:32][C:33]([NH:35][C:36]4[CH:45]=[C:44]5[C:39]([CH:40]=[CH:41][C:42]([S:46]([O-:49])(=[O:47])=[O:48])=[CH:43]5)=[CH:38][CH:37]=4)=[O:34])=[CH:29]3)=[CH:24][CH:23]=2)(=[O:20])=[O:21])[CH:15]=[CH:16][CH:17]=1)([OH:11])(=[O:10])=[O:8]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 9853268HCID 9853268, compound

Product 1

HCID 131725845HCID 131725845, compound

Procedure

To 8 mg (0.011 mmol) of compound 8 was added 2 mL of 5 N NaOH. The reaction was allowed to stir at ambient temperature for 6 hours. The reaction was acidified with 6 N HCl and the solution was added to a small reverse-phase (C18) solid phase extraction column. The column was washed with H2O followed by 50:50 (v:v) CH3CN:H2O to elute the product. This provided 5 mg of compound 12.

Workup

additionthe solution was added to a small reverse-phase (C18) solid phase extraction column
washThe column was washed with H2O
washH2O to elute the product

Sources & evidence

ORD record: ord-cfbc990807b743f29b14ef279f7a239c
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071231B2

Reaction notes

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