Hydrochloric Acid → HCID 22041800, compound

HRID 1791072Notes

Reaction equation

HRID 1791072 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([C:12]([NH:14][C:15]3[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=3)[C:18]([O:20]C)=[O:19])=[O:13])=[CH:9]2)=[CH:4][CH:3]=1.CO.[OH-].[Li+].Cl>O>[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([C:12]([NH:14][C:15]3[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=3)[C:18]([OH:20])=[O:19])=[O:13])=[CH:9]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 22041832HCID 22041832, compound

Product 1

HCID 22041800HCID 22041800, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 51 mg (0.16 mmol) of compound 111 was added 1 mL of methanol. 1 mL of water, and 800 μL of 1N lithium hydroxide (aqueous). The reaction was allowed to stir for 16 hours at ambient temperature. The pH of the solution was lowered to 3 with 1N HCl (aqueous) and the volatiles removed in vacuo. The resulting solid was suspended in water and collected by vacuum filtration. This provided 16 mg of compound 115.

Workup

  1. customthe volatiles removed in vacuo
  2. filtrationcollected by vacuum filtration

Sources & evidence

ORD record
ord-f9be0e01620342b8a8afc6d51c128097
Source dataset
uspto-grants-2006_07
Patent number
US07071231B2

Reaction notes

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