Phosphorus oxychloride → HCID 22041795, compound

HRID 1791078Notes

Reaction equation

HRID 1791078 reaction equation
[Na+].[C:2]([NH:5][C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][C:12]([S:16]([O-:19])(=O)=[O:17])=[CH:13]2)=[CH:8][CH:7]=1)(=[O:4])[CH3:3].P(Cl)(Cl)([Cl:22])=O>CC(N(C)C)=O>[Cl:22][S:16]([C:12]1[CH:13]=[C:14]2[C:9]([CH:8]=[CH:7][C:6]([NH:5][C:2](=[O:4])[CH3:3])=[CH:15]2)=[CH:10][CH:11]=1)(=[O:19])=[O:17]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 23678692HCID 23678692, compound

Product 1

HCID 22041795HCID 22041795, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

To 3.6 g (12.5 mmol) of compound 130 was added 100 mL of phosphorous oxychloride. Then, 4 mL of dimethylacetamide was added dropwise. The reaction was allowed to stir at ambient temperature for 5 hours and then was poured onto 2 L of ice. After the ice had melted, the solid precipitate was collected by vacuum filtration and was washed with water. After drying in vacuo, this provided 3.4 g of compound 131.

Workup

  1. filtrationthe solid precipitate was collected by vacuum filtration
  2. washwas washed with water
  3. customAfter drying in vacuo

Sources & evidence

ORD record
ord-db77f95e579e42a3a79ed51eedf09b95
Source dataset
uspto-grants-2006_07
Patent number
US07071231B2

Reaction notes

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