Sodium Hydroxide → HCID 178436303, compound

HRID 1791350Notes

Reaction equation

HRID 1791350 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6]#[N:7])[CH3:2].Cl.[NH2:12][OH:13].[OH-].[Na+]>C(O)C>[CH2:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6]([NH:12][OH:13])=[NH:7])[CH3:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 96692Benzonitrile, 3-ethyl-HCID 443297Hydroxyamine hydrochloride

Product 1

HCID 178436303HCID 178436303, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Ethyl-benzonitrile (400 mg, 3.05 mmol) with 5 M hydroxylamine hydrochloride (0.61 mL) and 1 M sodium hydroxide (3.05 mL) in ethanol (3 mL) were stirred at room temperature for 60 h. Work up as in example 4 afforded 230 mg (46%) of 3-ethyl-N-hydroxy-benzamidine.

Sources & evidence

ORD record
ord-08c518ddca984a52aaff357143fecc4d
Source dataset
uspto-grants-2006_07
Patent number
US07074809B2

Reaction notes

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