反应详情

To the 0.25 M 5-methyl-2-pyridinylmagnesium bromide of THF solution (20 mL, 5 mmol), DMF (0.773 mL, 10 mmol) was added at room temperature under argon. The reaction mixture was stirred for 10 min. and concentrated in vacuo. The residue was quenched with saturated ammonium chloride and dichloromethane. The organic layer was dried and the product was purified by silica gel column chromatography with 20% ethyl acetate in hexanes to give 379 mg (62.6%) of the title compound. GC-MS (M+): 121.

1. concentrationconcentrated in vacuo
2. customThe residue was quenched with saturated ammonium chloride and dichloromethane
3. customThe organic layer was dried
4. customthe product was purified by silica gel column chromatography with 20% ethyl acetate in hexanes