反应详情

温度

100 °C

A mixture of 4-chloro-7-(3-(1,1-dioxothiomorpholino)propoxy)-6-methoxyquinazoline (220 mg, 0.57 mmol), potassium carbonate (106 mg, 0.77 mmol) and 7-hydroxyquinoline (111 mg, 0.76 mmol) in DMF (7.5 ml) was stirred at 100° C. for 5 hours then allowed to cool to ambient temperature. The reaction mixture was treated with 1M aqueous sodium hydroxide solution (40 ml) and stirred at ambient temperature for a few minutes. The crude solid was collected by filtration washing with water. The resultant solid was dissolved in dichloromethane (2 ml) and was filtered through phase separating paper. The filtrate was evaporated under vacuum to give a solid residue which was triturated with ether, filtered and dried to give 7-(3-(1,1-dioxothiomorpholino)propoxy)-6-methoxy-4-(quinolin-7-yloxy)quinazoline (205 mg, 73%).

1. temperatureto cool to ambient temperature
2. stirringstirred at ambient temperature for a few minutes
3. filtrationThe crude solid was collected by filtration
4. washwashing with water
5. dissolutionThe resultant solid was dissolved in dichloromethane (2 ml)
6. filtrationwas filtered through phase
7. customseparating paper
8. customThe filtrate was evaporated under vacuum
9. customto give a solid residue which
10. customwas triturated with ether
11. filtrationfiltered
12. customdried