反应详情

温度

100 °C

A mixture of 4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline (225 mg, 0.67 mmol), (prepared as described for the starting material in Example 1), potassium carbonate (106 mg, 0.77 mmol) and 5-hydroxyquinoline (111 mg, 0.77 mmol) in DMF (7.5 ml) was stirred at 100° C. for 5 hours and allowed to cool to ambient temperature. The reaction mixture was treated with 1.0 N aqueous sodium hydroxide solution (40 ml) and allowed to stir at ambient temperature for a few minutes. The resulting precipitate was filtered off, washed with water and air dried for a short while. The damp solid was dissolved in dichloromethane, filtered through phase separating paper and the filtrate evaporated under vacuum. The residue was triturated with ether, filtered and dried to give 6-methoxy-7-(3-morpholinopropoxy)-4-(quinolin-5-yloxy)-quinazoline (178 mg, 59%).

1. custom(prepared
2. temperatureto cool to ambient temperature
3. stirringto stir at ambient temperature for a few minutes
4. filtrationThe resulting precipitate was filtered off
5. washwashed with water and air
6. customdried for a short while
7. dissolutionThe damp solid was dissolved in dichloromethane
8. filtrationfiltered through phase
9. customseparating paper
10. customthe filtrate evaporated under vacuum
11. customThe residue was triturated with ether
12. filtrationfiltered
13. customdried