HCID 69111912, compound → HCID 69111274, compound

HRID 1791885Notes

Reaction equation

HRID 1791885 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([S:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N+:17]([O-])=O)[CH:7]=[CH:6][C:5]=1[NH:20][C:21](=[O:24])[CH2:22][CH3:23].[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([S:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[NH2:17])[CH:7]=[CH:6][C:5]=1[NH:20][C:21](=[O:24])[CH2:22][CH3:23]

Participants

5

Reactant 2

HCID 69111912HCID 69111912, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69111274HCID 69111274, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 5-(2-nitro-phenylsulfanyl)-2-propionylamino-benzoic acid methyl ester (110 mg, 0.31 mmol, prepared according to Sevbo et al. 1976) and palladium-on-charcoal (10%, 25 mg) in ethyl acetate (5 mL) was stirred in an atmosphere of hydrogen (1 atm) at room temperature for 2 hours. The catalyst was filtered off and the solvent was removed by evaporation to yield the title compound quantitatively.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-c4624dff17464e99b1a38f46df62301a
Source dataset
uspto-grants-2006_07
Patent number
US07074831B2

Reaction notes

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