1-Indanone → Indene

HRID 1791967Notes

Reaction equation

HRID 1791967 reaction equation
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[BH4-].[Na+].O1CCCC1>CO>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

5

Reactant 3

HCID 67351-IndanoneHCID 8028TetrahydrofuranHCID 4311764Sodium borohydride

Product 1

HCID 7219Indene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Alternatively, the keto group in the indanone may simply be reduced under standard conditions (e.g. sodium borohydride in methanol and/or tetrahydrofuran (THF)) followed by dehydration to form the desired indene or indene skeleton-containing compound.

Sources & evidence

ORD record
ord-0cb5f17bb55a4411a16162629ce0c187
Source dataset
uspto-grants-2006_07
Patent number
US07074863B2

Reaction notes

Loading…