HRID1792021

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

反应SMILES：CCOC(=O)Cn1c(=O)c2c(nc(N3CCN(C(=O)OC(C)(C)C)CC3)n2-c2ccccc2OC)n(C)c1=O

HCID23536963

未命名化合物

PRODUCTS

产物

反应SMILES：CCOC(=O)Cn1c(=O)c2c(nc(N3CCNCC3)n2-c2ccccc2OC)n(C)c1=O.O=C(O)C(F)(F)F

HCID69542360

未命名化合物

PROCEDURE

实验过程

4-[7-(2-Methoxyphenyl)-1-(ethoxycarbonylmethyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (10 mg) was dissolved in trifluoroacetic acid (0.5 ml), and the reaction mixture was stirred at room temperature for 30 minutes. After the solvent was removed, the residue was purified by reversed phase high performance liquid chromatography to give 4.92 mg of the title compound.

WORKUP

后处理

customAfter the solvent was removed
customthe residue was purified by reversed phase high performance liquid chromatography

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-518e1b1ab51c4b65998c1f7a79d814ce
来源数据集: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07074798B2
来源说明: uspto-grants-2006_07

反应SMILES

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])[C:21]3[C:20](=[O:31])[N:19]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[C:18](=[O:38])[N:17]([CH3:39])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43]>>[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43].[CH2:36]([O:35][C:33](=[O:34])[CH2:32][N:19]1[C:20](=[O:31])[C:21]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:15][C:16]=2[N:17]([CH3:39])[C:18]1=[O:38])[CH3:37]