Trifluoroacetic acid → HCID 69542360, compound

HRID 1792021Notes

Reaction equation

HRID 1792021 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])[C:21]3[C:20](=[O:31])[N:19]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[C:18](=[O:38])[N:17]([CH3:39])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43]>>[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43].[CH2:36]([O:35][C:33](=[O:34])[CH2:32][N:19]1[C:20](=[O:31])[C:21]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:15][C:16]=2[N:17]([CH3:39])[C:18]1=[O:38])[CH3:37]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 235369634-[7-(2-Methoxyphenyl)-1-(ethoxycarbonylmethyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 69542360HCID 69542360, compound

Procedure

4-[7-(2-Methoxyphenyl)-1-(ethoxycarbonylmethyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (10 mg) was dissolved in trifluoroacetic acid (0.5 ml), and the reaction mixture was stirred at room temperature for 30 minutes. After the solvent was removed, the residue was purified by reversed phase high performance liquid chromatography to give 4.92 mg of the title compound.

Workup

  1. customAfter the solvent was removed
  2. customthe residue was purified by reversed phase high performance liquid chromatography

Sources & evidence

ORD record
ord-518e1b1ab51c4b65998c1f7a79d814ce
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

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