Trifluoroacetic acid → HCID 22029891, compound

HRID 1792034Notes

Reaction equation

HRID 1792034 reaction equation
Cl[C:2]1[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[C:9]2[C:8](=[O:18])[N:7]([CH3:19])[C:6](=[O:20])[N:5]([CH3:21])[C:4]=2[N:3]=1.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[N:10]1[C:9]2[C:8](=[O:18])[N:7]([CH3:19])[C:6](=[O:20])[N:5]([CH3:21])[C:4]=2[N:3]=[C:2]1[N:10]1[CH2:9][CH:4]2[CH2:23][CH:24]1[CH2:2][NH:3]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 30557721H-Purine-2,6-dione, 3,7-dihydro-8-chloro-7-(2-chlorophenyl)-1,3-dimethyl-

Product 1

HCID 22029891HCID 22029891, compound

Conditions

Temperature
150 °C

Procedure

2,5-(Diaza-bicyclo[2.2.1]heptane)-2-carboxylic acid tert-butyl ester (50 mg) and 8-chloro-7-(2-chlorophenyl)-1,3-dimethyl-3,7-dihydropurine-2,6-dione (10 mg) were mixed, and the mixture was stirred at 150° C. for 3 hours. The residue was dissolved in trifluoroacetic acid, and the solution was concentrated. The residue was purified by reversed phase high performance liquid chromatography to give 5.10 mg of the title compound.

Workup

  1. concentrationthe solution was concentrated
  2. customThe residue was purified by reversed phase high performance liquid chromatography

Sources & evidence

ORD record
ord-1f9c3b3406294c98a9964679f62bb457
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

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