反应详情

Benzyl bromide (100 ml) was added dropwise to a suspension of guanosine (100 g) in dimethyl sulfoxide (500 ml) at room temperature, and the resulting reaction mixture was stirred at room temperature for 4 hours. Then, concentrated hydrochloric acid (250 ml) was added thereto. The reaction mixture was stirred at room temperature for 30 minutes, poured into methanol (3 L), and stirred overnight. Deposited crystals were collected by filtration, washed with methanol, and then dried by ventilation at 60° C. for 24 hours to give 82.5 g of the title compound.

1. customthe resulting reaction mixture
2. stirringThe reaction mixture was stirred at room temperature for 30 minutes
3. stirringstirred overnight
4. filtrationDeposited crystals were collected by filtration
5. washwashed with methanol
6. customdried by ventilation at 60° C. for 24 hours