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Method 2) 80 g of 6-bromo-3-iodoimidazo[1,2-a]pyridine (compound in Production Example 49) was dissolved in 500 mL tetrahydrofuran, and 273 mL of 1.0 M isopropyl magnesium bromide in tetrahydrofuran was slowly added dropwise thereto at 0° C. and stirred for 30 minutes, and 380 mL of 68 g 4-toluenesulfonyl cyanide in tetrahydrofuran was added dropwise slowly over 1 hour, and the mixture was stirred for additional 1.5 hours. The reaction solution was poured into iced water, diluted with ethyl acetate and filtered through Celite. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate, and the collected organic layer was washed with brine. The organic layer was dried over anhydrous sodium sulfate and filtered through NH silica gel. Solid obtained by removing the solvent was triturated with diethyl ether, collected by filtration and washed with hexane to give 39.4 g of the title compound (brown solid).

1. stirringthe mixture was stirred for additional 1.5 hours
2. filtrationfiltered through Celite
3. customThe organic layer was separated
4. extractionthe aqueous layer was extracted with ethyl acetate
5. washthe collected organic layer was washed with brine
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. filtrationfiltered through NH silica gel
8. customSolid obtained
9. customby removing the solvent
10. customwas triturated with diethyl ether
11. filtrationcollected by filtration
12. washwashed with hexane