反应详情

温度

110 °C

1.04 g (5 mmol) of 3-ethoxycarbonyl-4-trifluoromethyl-1H-pyrrole and 0.818 g (5 mmol) of 1-chloroisoquinoline are added to 1.73 g (12.5 mmol) of potassium carbonate suspended in 10 mL of dimethyl sulphoxide at a temperature in the region of 20° C. under an argon atmosphere. After stirring for 17 hours at a temperature in the region of 110° C., the reaction mixture is cooled and then diluted with 30 mL of water. The solid formed is filtered off and washed with water and then oven-dried under reduced pressure (2.7 kPa), giving 1.46 g of 3-ethoxycarbonyl-4-trifluoromethyl-1-(isoquinolin-1-yl)-1H-pyrrole in the form of cream-colored crystals. IR spectrum (KBr), 3159; 2983; 2937; 1721; 1628; 1555; 1534; 1502; 1405; 1343; 1290; 1272; 1215; 1179; 1151; 1135; 1120; 1035; 831; 809; 755; 679 and 674 cm−1. Mass spectrum (EI) m/e 334 (M+.), m/e 289.

1. temperaturethe reaction mixture is cooled
2. customThe solid formed
3. filtrationis filtered off
4. washwashed with water
5. customoven-dried under reduced pressure (2.7 kPa)