反应详情

温度

140 °C

To a solution of 0.21 g of ethyl N-[2-[2-(5-cyano-2-methoxybenzenesulfonylamino)ethyl]-5-isopropylphenyl]oxalamate in 3 mL of N,N-dimethylformamide was added 56 mg of lithium chloride, and the mixture was stirred at 140° C. for 4 hours. To the reaction mixture was added 1 mol/L hydrochloric acid, and the mixture was extracted with ethyl acetate. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed under reduced pressure to give 0.198 g of N-[2-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-5-isopropylphenyl]oxalamic acid.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialAfter the organic layer was dried over anhydrous sodium sulfate
3. customthe solvent was removed under reduced pressure